Using MOFA for integration of omics data

Using MOFA for integration of omics data

Target Audience:
15 June 2020

General context

This training provides an introduction to Multi-Omics Factor Analysis (MOFA) for the integration of different omic data sets in an unsupervised fashion. It will enable you to run MOFA on multi-omic data, identify and explore the major drivers of variations across omics and use the inferred factors in various downstream analyses.

This training is organised in collaboration with the Helis Academy. More information see https://helisacademy.com/nl/data-analysis-stewardship

Interreg

Objectives

Participants can bring their own data to the course.

Approach
  • What kind of preprocessing of the data is required for MOFA?
  • How to train MOFA on a multi-omic data set?
  • How to interpret the MOFA factors by their loadings, using gene set enrichment or sample ordination?
  • How to use MOFA for downstream analyses including regression, classification or clustering?
  • How to impute missing values with MOFA?
  • How to select the number of factors and compare different MOFA fits?
Required skills

Familiarity with R and RStudio.

Software demonstrated

MOFA (Multi‐Omics Factor Analysis—a framework for unsupervised integration of multi‐omics data sets) - http://msb.embopress.org/content/14/6/e8124

Trainers

Ricard Argelaguet

Predoctoral Fellow in the Stegle  and Marioni research group of the European Bioinformatics Institute

Program

-

TBC

Practical info

15 June 2020

iGent

Technologiepark-Zwijnaarde 126
9052 Gent
Belgium

15 June 2020

iGent
Public transport

Several buses drive between Gent Sint-Pieters railway station and Technologiepark: Bus 70, 71 and 72 (‘Tramstraat’)

  • Get off at the stop marked 'Bollebergen' at Grote Steenweg Noord.

  • Technologiepark is straight in front of you on the other side of the soft verge.

  • Walk into the park to the roundabout. You can see the iGent Tower on your left.

Shuttle bus

  • The shuttle service between Gent Sint-Pieters and Technologiepark runs every 15 minutes during peak hours (7.30 - 9.30 am and 4.30 - 6.30 pm).

  • The site has four stops, including one nearly in front of the iGent Tower (4th stop).

  • More info on the Tech Lane Ghent Science Park site.

15 June 2020

iGent
Parking

You can park your car on the Tech Lane Ghent Science park in the open car parks (no barriers), like the one in front of the iGent tower across the road. These car parks have Dutch signs which read "Parkeren uitsluitend met vignet! (overtreding = wielklem)”. This means you should only park there if you have a valid car park permit. You can request such a permit by sending an email to your contact person at iGent. The permit is only valid for a single day, and will need to be placed visibly behind the car's windscreen.

15 June 2020

iGent

Contact

VIB training
Tel: +32 9 244 66 11
Mail: training@vib.be