Functional analysis: the biology behind the genes
25 October
General context
This course will guide you into the steps of how to get the answers about what the genes can tell you! With the advances of technology, understanding the load of informations and giving it some meaning is becoming more challenging. To help you through this adventure and to get the answers your data is anxious to show you, we will use ONLINE tools to annotate and analyse some Human and Plant datasets and by the end of the day everything will make sense! We will shortly talk about how to start if you work with an organism that doesn't have a Reference genome.
We will use Gene Ontology, Gene enrichment as much as Pathways to interpret our data and unravel the meaning of our gene set. This introduction of Functional Analysis will elucidate the biology behind the gene and bring to light what your data means.
Explain the basic concepts and terminology of functional analysis, such as gene ontology, gene enrichment, pathways, and networks.
Use online tools to annotate and analyse human and plant datasets.
Compare and contrast different organisms, including those without a reference genome, in terms of their functional analysis.
Briefly evaluate the biological significance of the gene sets obtained from functional analysis.
Trainers
Bruna Piereck
Bruna Piereck is a bioinformatics trainer at VIB and ELIXIR-BE training coordinator deputy. She obtained a Master and PhD degree in Molecular Genetics, with a focus on Bioinformatics from the Federal University of Pernambuco, Brazil, in 2019. During her PhD, she had the chance to collaborate with the university of Luxembourg and the McGill university in Quebec Canada for a short time. Ever since she has been involved with teaching and research and Since March 2022, she joined VIB with the mission of teaching and assist other trainers in a variety of topics.
Mainak Guharoy
Mainak Guharoy, PhD works as a Multiomics Data Expert at the VIB Metabolomics Core Facility, Leuven. His work involves the development of computational methods to analyze (multi)omics datasets obtained from cellular and pathological samples. A particular focus is on leveraging interactomics and complexomics-based approaches for the biological interpretation of omics data. See for example this preprint for an idea about their latest work.
Program
Experiment context and quality control
Organism without Reference Genome
Coffee break
Enrichment and Overrepresentation analysis (ORA)
Lunch
Gene ontology enrichment
Coffee break
Pathway (Networks) and gene functions
Gene-set enrichment
Practical info
25 October 2024
Ghent - VIB/UGent FSVM II
Technologiepark 75
9052 Zwijnaarde
Belgium
25 October 2024
Ghent - VIB/UGent FSVM II
From Ghent Sint-Pieters station, you can take a bus to Technologiepark. Please check Routeplanner De Lijn for schedules.
25 October 2024
Ghent - VIB/UGent FSVM II
Looking for a custom cycling route? Try the online cycling route planner to easily and quickly identify the fastest, safest and/or most scenic route to any destination in Ghent.
Cycling route planner
Shared bicycles:
Several providers are active in the area.
Take a look at their platforms:
- Indigo Weel Pro app
- Bluebike
- DOTT
- BOLT eBikes
- Donkey Republic
There are also some public bicycle pumps at the park.
25 October 2024
Ghent - VIB/UGent FSVM II
There is only one entrance to Technologiepark. At the entrance, please take a ticket - Parking is only allowed in regular parking spots (for instance in front of the building) and in the parking tower. Parking alongside the roads or in other places where there is no regular parking is prohibited.
25 October 2024
Ghent - VIB/UGent FSVM II
Room: L4 - 4th floor