Liquid-Liquid Phase Separation, cancelled

Liquid-Liquid Phase Separation, cancelled

31 March 2020

Leuven, Provinciehuis Vlaams-Brabant

Liquid-Liquid Phase Separation, cancelled

Target Audience:

Leuven, Provinciehuis Vlaams-Brabant

31 March 2020
FacebookTwitterLinkedin

General context

Due to Coronavirus spreading in Belgium and Europe, VIB has made the difficult decision to cancel the Training on Liquid-Liquid Phase Separation. Possibly, the organizing committee will look for another date later this year or next year. We will keep you updated.

More info and recommendations can be found here.

 

The concept of liquid-liquid phase separation provides a rationale for the cellular organization of cytoplasmic and nuclear components into biomolecular condensates. These biomolecular condensates can serve as specialized regions for biochemical reactions, dynamically sequester components or act as organizational hubs for signaling networks. In recent years, the interests in how these biomolecular condensates are formed, how they are organized, and what their functional properties are has grown substantially, and has led to increasing evidence that dysregulation of liquid-liquid phase separation contributes to neurodegenerative diseases as well as cancer. To keep up to date with the latest developments and break-throughs in this field, we organize a VIB training day on ‘Liquid-Liquid Phase Separation’.

Objectives

The aim of this training day is – after a brief introduction – to provide guidelines for accurate experimental characterization of LLPS processes in vitro and in cells. We will end the day with a discussion on the implications of dysregulation of liquid-liquid phase separation for human disease. We have invited top-notch speakers on this topic to inform you on the latest developments.  

Event intended for

This training targets scientists who want to keep up-to-date with the latest evolutions in the field of liquid-liquid phase separation. The training is aimed at PhD students, postdoctoral fellows, technicians or other scientists with a molecular biology background.

Scientific committee

Eleonora Leucci, Department of Oncology, KU Leuven

Thomas Moens, VIB-KU Leuven Center for Brain & Disease Research

Peter Tompa, VIB-VUB Center for Structural Biology

Extra information
  • Participation is free for VIB participants.
  • Registration fee for Academics from Universities and Research Centers is € 50 (21% VAT incl.).
  • Registration fee for participants of EU-LIFE partner institutes is € 50 (21% VAT incl.).
  • Registration fee for industry is € 300 (21% VAT incl.).
  • Note that upon no-show without valid justification you will be blacklisted for the VIB training program for 1 year and for VIB participants the reimbursement of the catering costs (€ 50) will be charged to the research group. Click here for more information.

Trainers

Steven Boeynaems
Department of Genetics, Stanford University School of Medicine, US
Alex Holehouse
Department of Biochemistry & Molecular Biophysics, Washington University School of Medicine, US
Avinash Patel
Dewpoint Therapeutics, Dresden, DE
Gian Gaetano Tartaglia
Centre for Genomic Regulation, The Barcelona Institute for Science and Technology, Universitat Pompeu Fabra, Institució Catalana de Recerca i Estudis Avançats, ES
Saskia Hutten
BioMedical Center, Cell Biology, Ludwig-Maximilians-University Munich, DE
Kaveh Daneshvar
Harvard Medical School, Massachusetts General Hospital, US
Magdalini Polymenidou
Institute of Molecular Life Sciences, University of Zurich, CH
Ina Vorberg
German Center for Neurodegenerative Diseases Bonn (DZNE), Bonn, DE

Program

-

Welcome

Introduction

Engineering protein phase separation: decoding/encoding function in natural and synthetic systems
-

Steven Boeynaems, Department of Genetics, Stanford University School of Medicine, US 

TBA
-

Alex Holehouse, Department of Biochemistry & Molecular Biophysics, Washington University School of Medicine, US

-

Coffee

In vitro assays

Biochemical reconstitution of biomolecular condensates to interrogate cell physiology and disease
-

Avinash Patel, Dewpoint Therapeutics, Dresden, DE

The role of coding and non-coding RNAs and phase separation in the post-transcriptional regulation of the genome
-

Gian Gaetano Tartaglia, Centre for Genomic Regulation, The Barcelona Institute for Science and Technology, Universitat Pompeu Fabra, ICREA, ES

-

Lunch

Function of condensates

Control of phase separation by nuclear import receptors
-

Saskia Hutten, BioMedical Center, Cell Biology, Ludwig-Maximilians-University Munich, DE

Control of gene activation by phase-separated lncRNA-protein condensates
-

Kaveh Daneshvar, Harvard Medical School, Massachusetts General Hospital, US

-

Coffee

Dysregulation of phase separation and its implications

Unravelling the physiological and pathological states of the most important protein players in ALS and FTD
-

Magdalini Polymenidou, Institute of Molecular Life Sciences, University of Zurich, CH

TBA
-

Ina Vorberg, German Center for Neurodegenerative Diseases Bonn (DZNE), Bonn, DE

Practical info

Provinciehuis Vlaams-Brabant

Provincieplein 1
3010 Leuven
Belgium

Provinciehuis Vlaams-Brabant
Public transport

Leuven is easy to reach by train from all Belgian and European cities. Leuven is a 20-minute train ride from Brussels, 45 minutes from Antwerp, 50 minutes from Liège, 1.5 hours from Paris and 2.5 hours from London, Amsterdam or Cologne.

www.belgianrail.be

Provinciehuis Vlaams-Brabant
Parking

Leuven is located at the junction of two important highways: the E40 and the E314. The 'P' signposts will guide you to the different car parks. If you are using a GPS, please enter “Tiensevest” and not “Provincieplein 1”.

Car parks in Leuven

Site plan

Provinciehuis Vlaams-Brabant
Location contact

+32 16 26 70 15

provinciehuis@vlaamsbrabant.be

Contact

VIB training
Tel: +32 9 244 66 11
Mail: training@vib.be