Liquid-Liquid Phase Separation, cancelled
Liquid-Liquid Phase Separation, cancelled
General context
Due to Coronavirus spreading in Belgium and Europe, VIB has made the difficult decision to cancel the Training on Liquid-Liquid Phase Separation. Possibly, the organizing committee will look for another date later this year or next year. We will keep you updated.
More info and recommendations can be found here.
The concept of liquid-liquid phase separation provides a rationale for the cellular organization of cytoplasmic and nuclear components into biomolecular condensates. These biomolecular condensates can serve as specialized regions for biochemical reactions, dynamically sequester components or act as organizational hubs for signaling networks. In recent years, the interests in how these biomolecular condensates are formed, how they are organized, and what their functional properties are has grown substantially, and has led to increasing evidence that dysregulation of liquid-liquid phase separation contributes to neurodegenerative diseases as well as cancer. To keep up to date with the latest developments and break-throughs in this field, we organize a VIB training day on ‘Liquid-Liquid Phase Separation’.
The aim of this training day is – after a brief introduction – to provide guidelines for accurate experimental characterization of LLPS processes in vitro and in cells. We will end the day with a discussion on the implications of dysregulation of liquid-liquid phase separation for human disease. We have invited top-notch speakers on this topic to inform you on the latest developments.
This training targets scientists who want to keep up-to-date with the latest evolutions in the field of liquid-liquid phase separation. The training is aimed at PhD students, postdoctoral fellows, technicians or other scientists with a molecular biology background.
Eleonora Leucci, Department of Oncology, KU Leuven
Thomas Moens, VIB-KU Leuven Center for Brain & Disease Research
Peter Tompa, VIB-VUB Center for Structural Biology
- Participation is free for VIB participants.
- Registration fee for Academics from Universities and Research Centers is € 50 (21% VAT incl.).
- Registration fee for participants of EU-LIFE partner institutes is € 50 (21% VAT incl.).
- Registration fee for industry is € 300 (21% VAT incl.).
- Note that upon no-show without valid justification you will be blacklisted for the VIB training program for 1 year and for VIB participants the reimbursement of the catering costs (€ 50) will be charged to the research group. Click here for more information.
Trainers
Steven Boeynaems
Alex Holehouse
Avinash Patel
Gian Gaetano Tartaglia
Principal investigator - Senior researcher tenured
RNA systems biology
Saskia Hutten
Kaveh Daneshvar
Magdalini Polymenidou
Ina Vorberg
Program
Welcome
Introduction
Engineering protein phase separation: decoding/encoding function in natural and synthetic systems
Steven Boeynaems, Department of Genetics, Stanford University School of Medicine, US
TBA
Alex Holehouse, Department of Biochemistry & Molecular Biophysics, Washington University School of Medicine, US
Coffee
In vitro assays
Biochemical reconstitution of biomolecular condensates to interrogate cell physiology and disease
Avinash Patel, Dewpoint Therapeutics, Dresden, DE
The role of coding and non-coding RNAs and phase separation in the post-transcriptional regulation of the genome
Gian Gaetano Tartaglia, Centre for Genomic Regulation, The Barcelona Institute for Science and Technology, Universitat Pompeu Fabra, ICREA, ES
Lunch
Function of condensates
Control of phase separation by nuclear import receptors
Saskia Hutten, BioMedical Center, Cell Biology, Ludwig-Maximilians-University Munich, DE
Control of gene activation by phase-separated lncRNA-protein condensates
Kaveh Daneshvar, Harvard Medical School, Massachusetts General Hospital, US
Coffee
Dysregulation of phase separation and its implications
Unravelling the physiological and pathological states of the most important protein players in ALS and FTD
Magdalini Polymenidou, Institute of Molecular Life Sciences, University of Zurich, CH
TBA
Ina Vorberg, German Center for Neurodegenerative Diseases Bonn (DZNE), Bonn, DE
Practical info
Leuven - Provinciehuis Vlaams-Brabant
Provincieplein 1
3010 Leuven
Belgium
Leuven - Provinciehuis Vlaams-Brabant
Provinciehuis Vlaams-Brabant is located within walking distance of the Leuven railway and bus station. When exiting the station, go left across the Roger Van Overstraetenplein.
Leuven - Provinciehuis Vlaams-Brabant
There is a dedicated cycling path next to the Leuven ring road where you can ride in both directions. You can park your bike right next to or underneath the building. Using your bike for longer distances? Check out Cycle Highways?
Leuven - Provinciehuis Vlaams-Brabant
From the E40, take the E314 and immediately exit at junction 15 towards Leuven city center. Follow the road to the Leuven ring road, turn right towards Tienen and Diest, and continue past the Tiense Poort. As you approach the Provinciehuis, stay in the right lane and continue towards the station until the end. Then, carefully turn right and drive slowly, respecting pedestrians and cyclists, under the pedestrian bridge (Roger Van Overstraetenplein) until you reach the railway. Turn right and follow the tracks towards Provinciehuis.
Park on Bezoekersparking floor -2.
Using GPS? Older GPS software may not recognize 'Provincieplein' as an address. In that case, enter 'Tiensevest - intersection with Justus Lipsiusstraat' instead.
Leuven - Provinciehuis Vlaams-Brabant
+32 16 26 70 15
provinciehuis@vlaamsbrabant.be